Anti-Myelin Oligodendrocyte Glycoprotein Optic Neuritis Presenting with Dense Premacular Hemorrhage
نویسندگان
چکیده
منابع مشابه
Antibodies to myelin oligodendrocyte glycoprotein in idiopathic optic neuritis
OBJECTIVES To investigate the differences of clinical features, cerebrospinal fluid (CSF), MRI findings and response to steroid therapies between patients with optic neuritis (ON) who have myelin oligodendrocyte glycoprotein (MOG) antibodies and those who have seronegative ON. SETTING We recruited participants in the department of neurology and ophthalmology in our hospital in Japan. METHOD...
متن کاملAnti-myelin oligodendrocyte glycoprotein antibodies in pediatric patients with optic neuritis.
OBJECTIVE To study the humoral immune response directed at myelin oligodendrocyte glycoprotein (MOG)in pediatric patients with isolated and recurrent optic neuritis(ON). DESIGN Observational prospective case series. SETTING Six pediatric hospitals in Germany and Austria. PATIENTS Thirty-seven patients 18 years or younger with single or recurrent episodes of ON were recruited from 6 differ...
متن کاملClinical Profile of Anti-Myelin Oligodendrocyte Glycoprotein Antibody Seropositive Cases of Optic Neuritis.
We have studied the clinical picture of anti-aquaporin antibody (AQP4-Ab)- and anti-myelin oligodendrocyte glycoprotein antibody (MOG-Ab)-positive optic neuritis. However, optic neuritis associated with MOG-Abs has not been elucidated using new methods such as cell-based assay. Hence, we conducted a comprehensive investigation on its clinical profile. Serum samples from 70 patients (17 males an...
متن کاملMyelin-Oligodendrocyte Glycoprotein Antibodies Spectrum Disorders
Myelin-Oligodendrocyte Glycoprotein (MOG) is an adhesive molecule responsible for myelin sheath structural integrity and maintenance. Patients with spectrum of inflammatory demyelinating disease particularly in central nervous system are reported to have antibodies against this protein. Diseases such as multiple sclerosis, clinically isolated syndrome, neuro-myelitis optica (NMO) spectrum disor...
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Multiple sclerosis (MS) is considered to be an autoimmune disease of the central nervous system (CNS) that in many patients first presents clinically as optic neuritis. The relationship of optic neuritis to MS is not well understood. We have generated novel T cell receptor (TCR) transgenic mice specific for myelin oligodendrocyte glycoprotein (MOG). MOG-specific transgenic T cells are not delet...
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ژورنال
عنوان ژورنال: Ophthalmology
سال: 2019
ISSN: 0161-6420
DOI: 10.1016/j.ophtha.2019.07.004